Ultrasonic-assisted Extraction of Alkaloids from Semen Strychni by Response Surface Analysis 响应面法优化超声辅助提取马钱子中生物碱的工艺研究
Semen strychni pulveratum is a kind of fine powder by blending starch with grinding strychnos alkaloids. 为了使用药有效安全,将制马钱子细粉加淀粉勾兑而成马钱子粉。
Conclusion: Processed Products of Semen Strychni is lower toxicity than its crude drug, the study is useful to build up the standardization of Chinese herb slices. 结论:炮制可降低马钱子的毒性,不同炮制方法的减毒作用有差异,通过比较研究有利于实现饮片规范化、标准化。
Conclusion Semen Strychni and its processed products of Jiangxi methods and innovated methods can lower the toxicity and improve the safety of clinical use. 结论江西法及其改良法炮制的马钱子比其砂烫法和油炸法更易降低毒性,使其安全范围增大,从而提高其临床用药的安全性。
It has been called in question on clinical safety, even not accepted by international market, due to toxical Semen Strychni as monarch drug which often induce adverse reaction. 但因其君药马钱子毒性较大,临床常有不良反应报道,从而影响该药的临床安全使用及国际准入。
OBJECTIVE: To find a method which can analysis strychnine and brucine in semen strychni using 722 or 721 type spectrophotometer. 目的:探索一种用可见分光光度计分析马钱子中士的宁和马钱子碱的方法。
The high and middle dosage of Semen strychni 、 Brucine could promote DNA and proteoglycan synthesis of chondrocyte apparently. 对软骨细胞DNA、蛋白多糖、胶原合成的影响:马钱子、马钱子碱高中剂量组有明显促进兔软骨细胞DNA合成及分泌蛋白多糖的作用,且有一定的量效关系。
Determination of Apparent Pharmacokinetics Parameter of Ordinary Powder and Fine Powder of Semen Strychni with Drug Cumulative Method 药物累积法测定普通马钱子粉与超细马钱子粉的表观药动学参数
[ Results] The ten groups of stir-baked semen strychni in sand had nine common peak and better reproduction quality of relative retention time. The RSD was little than 0.36%. [结果]10批砂炒马钱子有9个共有峰,相对保留时间的重现性较好,RSD<0.36%;
The protect effect of Semen Strychni on knee OA in rabbit was observed in vivi. 方法:1.通过在体实验观察马钱子对兔膝骨关节炎的保护作用。
OBJECTIVE To investigate into the effect of fine levigation technique on the pharmacokinetics parameter of Semen Strychni. 目的研究超细粉体技术对马钱子药物动力学参数的影响。
Tissue distribution was studied in rats after administration of noisome gel of Semen Strychni alkaloids extract. 研究马钱子总碱囊泡凝胶经皮给药后大鼠的组织分布。
The influences on extraction efficiency of the alkaloids, including Semen strychni grain diameter, solvent concentration, solvent pH, ratio of liquid to solid, ultrasonic/ microwave power and extraction time, were analyzed. 实验考察了马钱子颗粒度,溶剂浓度和pH值,液料比,超声或微波功率和提取时间等因素对提取过程的影响。
This thesis focused on the microwave-assisted and ultrasonic-assisted extraction processes of alkaloids from Semen strychni. 本文主要对微波辅助提取和超声波辅助提取马钱子中生物碱的提取工艺进行了研究。
The method is accurate and reproducible, providing a new reference for quality control of Semen Strychni. 该研究方法为马钱子药材的质量控制提供了参考。
When particle size of semen strychni powder is controlled in the region of 100-200 mesh, the contents of brucine and strychnine vary little. 将马钱子粉粒径控制在100-200目之间时,马钱子碱、士的宁含量变化很小。
The HPLC fingerprint of Semen Strychni was established. 建立了马钱子药材HPLC指纹图谱。